Exploring manycore architectures for next-generation HPC systems through the MANGO approach

[EN] The Horizon 2020 MANGO project aims at exploring deeply heterogeneous accelerators for use in High-Performance Computing systems running multiple applications with different Quality of Service (QoS) levels. The main goal of the project is to exploit customization to adapt computing resources to reach the desired QoS. For this purpose, it explores different but interrelated mechanisms across the architecture and system software. In particular, in this paper we focus on the runtime resource management, the thermal management, and support provided for parallel programming, as well as introducing three applications on which the project foreground will be validated.This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 671668.Flich Cardo, J.; Agosta, G.; Ampletzer, P.; Atienza-Alonso, D.; Brandolese, C.; Cappe, E.; Cilardo, A.... (2018). Exploring manycore architectures for next-generation HPC systems through the MANGO approach. Microprocessors and Microsystems. 61:154-170. https://doi.org/10.1016/j.micpro.2018.05.011S1541706

Phenotypic Landscape of Saccharomyces cerevisiae during Wine Fermentation: Evidence for Origin-Dependent Metabolic Traits

The species Saccharomyces cerevisiae includes natural strains, clinical isolates, and a large number of strains used in human activities. The aim of this work was to investigate how the adaptation to a broad range of ecological niches may have selectively shaped the yeast metabolic network to generate specific phenotypes. Using 72 S. cerevisiae strains collected from various sources, we provide, for the first time, a population-scale picture of the fermentative metabolic traits found in the S. cerevisiae species under wine making conditions. Considerable phenotypic variation was found suggesting that this yeast employs diverse metabolic strategies to face environmental constraints. Several groups of strains can be distinguished from the entire population on the basis of specific traits. Strains accustomed to growing in the presence of high sugar concentrations, such as wine yeasts and strains obtained from fruits, were able to achieve fermentation, whereas natural yeasts isolated from “poor-sugar” environments, such as oak trees or plants, were not. Commercial wine yeasts clearly appeared as a subset of vineyard isolates, and were mainly differentiated by their fermentative performances as well as their low acetate production. Overall, the emergence of the origin-dependent properties of the strains provides evidence for a phenotypic evolution driven by environmental constraints and/or human selection within S. cerevisiae

Statins for primary prevention of cardiovascular disease and the risk of acute kidney injury

International audiencePURPOSE: To investigate the risk of acute kidney injury (AKI) in subjects initiating statin therapy for primary prevention of cardiovascular disease (CVD).METHODS: A nationwide cohort study using French hospital discharge and claims databases was performed, studying subjects from the general population aged 40 to 75 years in 2009, with no history of CVD and no lipid-lowering drugs during the preceding 3-year period, followed for up to 7 years. Exposure to statins (type, dose, and time since first use) and to other drugs for CVD risk was assessed. The primary outcome was hospital admission for AKI.RESULTS: The cohort included 8 236 279 subjects, 818 432 of whom initiated a statin for primary prevention. During 598 487 785 person-months exposed to statins, 700 events were observed, corresponding to an incidence of AKI of 4.59 per 10 000 person-years (7.01 in men, 3.01 in women). AKI mainly occurred in the context of organ failure, sepsis, and genitourinary disease. A 19% increased rate of AKI (hazard ratio = 1.19, 95%CI: 1.08-1.31) was observed in men exposed to statins, whereas no increase in the overall risk of AKI was observed in women. However, exposure to high-potency statins was associated with a 72% to 116% increased risk in both genders and a dose-effect relationship observed for rosuvastatin and atorvastatin. No temporal pattern of occurrence nor interaction with drugs for CVD risk was observed.CONCLUSIONS: Although the overall risk of AKI appears moderately increased, more attention should be paid to renal function in subjects taking statins for primary prevention both in clinical practice and from a research viewpoint

Evaluation by a Machine Learning System of Two Preparations for Small Bowel Capsule Endoscopy: The BUBS (Burst Unpleasant Bubbles with Simethicone) Study

Background: Bubbles often mask the mucosa during capsule endoscopy (CE). Clinical scores assessing the cleanliness and the amount of bubbles in the small bowel (SB) are poorly reproducible unlike machine learning (ML) solutions. We aimed to measure the amount of bubbles with ML algorithms in SB CE recordings, and compare two polyethylene glycol (PEG)-based preparations, with and without simethicone, in patients with obscure gastro-intestinal bleeding (OGIB). Patients & Methods: All consecutive outpatients with OGIB from a tertiary care center received a PEG-based preparation, without or with simethicone, in two different periods. The primary outcome was a difference in the proportions (%) of frames with abundant bubbles (>10%) along the full-length video sequences between the two periods. SB CE recordings were analyzed by a validated computed algorithm based on a grey-level of co-occurrence matrix (GLCM), to assess the abundance of bubbles in each frame. Results: In total, 105 third generation SB CE recordings were analyzed (48 without simethicone and 57 with simethicone-added preparations). A significant association was shown between the use of a simethicone-added preparation and a lower abundance of bubbles along the SB (p = 0.04). A significantly lower proportion of “abundant in bubbles” frames was observed in the fourth quartile (30.5% vs. 20.6%, p = 0.02). There was no significant impact of the use of simethicone in terms of diagnostic yield, SB transit time and completion rate. Conclusion: An accurate and reproducible computed algorithm demonstrated significant decrease in the abundance of bubbles along SB CE recordings, with a marked effect in the last quartile, in patients for whom simethicone had been added in PEG-based preparations, compared to those without simethicone

Un traitement chronique à l'apeline chez la souris obèse et résistante à l'insuline augmente l'oxydation des acides gras et la biogénèse mitochondriale dans le muscle

Communication orale ; http://www.lesjfn.f

Free-breathing diffusion-weighted single-shot echo-planar MR imaging using parallel imaging (GRAPPA 2) and high b value for the detection of primary rectal adenocarcinoma

Our objective was to determine the diagnostic accuracy of a free-breathing diffusion-weighted single-shot echo-planar magnetic resonance imaging (FBDW-SSEPI) technique with parallel imaging and high diffusion factor value (b = 1000 s/mm2) in the detection of primary rectal adenocarcinomas. Thirty-one patients (14M and 17F; mean age 67 years) with histopathologically proven primary rectal adenocarcinomas and 31 patients without rectal malignancies (14M and 17F; mean age 63.6 years) were examined with FBDW-SSEPI (repetition time (TR/echo time (TE) 3900/91 ms, gradient strength 45 mT/m, acquisition time 2 min) at 1.5 T using generalized autocalibrating partially parallel acquisitions (GRAPPA, acceleration factor 2) and a b value of 1000 s/mm2. Apparent diffusion coefficients (ADCs) of rectal adenocarcinomas and normal rectal wall were measured. FBDW-SSEPI images were evaluated for tumour detection by 2 readers. Sensitivity, specificity, accuracy and Youden score for rectal adenocarcinoma detection were calculated with their 95% confidence intervals (CI) for ADC value measurement and visual image analysis. Rectal adenocarcinomas had significantly lower ADCs (mean 1.036 × 10−3 ± 0.107 × 10−3 mm2/s; median 1.015 × 10−3 mm2/s; range (0.827–1.239) × 10−3 mm2/s) compared with the rectal wall of control subjects (mean 1.387 × 10−3 ± 0.106 × 10−3 mm2/s; median 1.385 × 10−3 mm2/s; range (1.176–1.612) × 10−3 mm2/s) (p < 0.0001). Using a threshold value ≤ 1.240 × 10−3 mm2/s, all rectal adenocarcinomas were correctly categorized and 100% sensitivity (31/31; 95% CI 95–100%), 94% specificity (31/33; 95% CI 88–100%), 97% accuracy (60/62; 95% CI 92–100%) and Youden index 0.94 were obtained for the diagnosis of rectal adenocarcinoma. FBDW-SSEPI image analysis allowed depiction of all rectal adenocarcinomas but resulted in 2 false-positive findings, yielding 100% sensitivity (31/31; 95% CI 95–100%), 94% specificity (31/33; 95% CI 88–100%), 97% accuracy (60/62; 95% CI 92–100%) and Youden index 0.94 for the diagnosis of primary rectal adenocarcinoma. We can conclude that FBDW-SSEPI using parallel imaging and high b value may be helpful in the detection of primary rectal adenocarcinomas

Évaluation de la démontabilité des convertisseurs électroniques de puissance pour une circularité améliorée

-Les convertisseurs d'électroniques de puissance (CEP) jouent un rôle crucial dans le fonctionnement de nombreux systèmes et appareils électriques modernes. Malgré leur utilisation répandue, l'absence d'un processus de démontage efficace et rentable pour ces dispositifs peut limiter leur réutilisation, leur réparabilité, leur refabrication et, en fin de compte, leur recyclabilité, entravant ainsi la circularité des produits. Afin de comprendre la circularité de ces produits, il est important d'évaluer la difficulté du désassemblage. Par conséquent, cet article étudie l'applicabilité de la facilité de désassemblage (eDiM), qui est référencée dans la norme EN 45554, pour analyser le désassemblage des produits électroniques à base de circuits imprimés (PCB). Après avoir identifié les limites de la méthode eDiM, nous avons affiné et adapté la méthode pour la rendre plus appropriée pour les CEP basés sur les PCB, et ainsi proposer une méthode d'évaluation de la démontabilité spécifique aux CEP basés sur les PCBs permettant la mise en oeuvre d'exigences quantifiables pour les produits soutenant l'économie circulaire. Par cette approche normalisée pour évaluer la facilité de démontage au niveau des PCB, facilitant ainsi l'identification des améliorations de conception susceptibles d'améliorer leur circularité, les décideurs politiques et les concepteurs peuvent contribuer plus efficacement à la transition vers une économie circulaire dans l'électronique des PCB et plus particulièrement dans l'électronique de puissance. Mots-clés-circularité, démontabilité, mesures de facilité de désassemblage, convertisseur électronique de puissance, réparation, carte de circuit imprimé

Brain glucagon-like peptide 1 signaling controls the onset of high-fat diet-induced insulin resistance, and reduces energy expenditure

Glucagon-like peptide-1 (GLP-1) is a peptide released by the intestine and the brain. We previously demonstrated that brain GLP-1 increases glucose-dependent hyperinsulinemia and insulin-resistance. These two features are major characteristics of the onset of type 2 diabetes. Therefore, we investigated whether blocking brain GLP-1 signaling would prevent high-fat diet (HFD)-induced diabetes in the mouse. Our data show that a one month chronic blockage of brain GLP-1 signaling by Exendin-9 (Ex9), totally prevented hyperinsulinemia and insulin-resistance in HFD mice. Furthermore, food intake was dramatically increased but body weight gain was unchanged, showing that brain GLP-1 controlled energy expenditure. Thermogenesis, glucose utilization, oxygen consumption, carbon dioxide production, muscle glycolytic respiratory index, UCP2 expression in muscle, and basal ambulatory activity were all increased by the Ex9 treatment. Thus we have demonstrated that in response to a high-fat diet, brain GLP-1 signaling induces hyperinsulinemia, insulin resistance, and decreases energy expenditure by reducing metabolic thermogenesis and ambulatory activity

Chromosome arm aneuploidies shape tumour evolution and drug response

Chromosome arm aneuploidies (CAAs) are pervasive in cancers. However, how they affect cancer development, prognosis and treatment remains largely unknown. Here, we analyse CAA profiles of 23,427 tumours, identifying aspects of tumour evolution including probable orders in which CAAs occur and CAAs predicting tissue-specific metastasis. Both haematological and solid cancers initially gain chromosome arms, while only solid cancers subsequently preferentially lose multiple arms. 72 CAAs and 88 synergistically co-occurring CAA pairs multivariately predict good or poor survival for 58% of 6977 patients,\ua0with negligible impact of whole-genome doubling. Additionally, machine learning identifies 31 CAAs that robustly alter response to 56 chemotherapeutic drugs across cell lines representing 17 cancer types. We also uncover 1024 potential synthetic lethal pharmacogenomic interactions. Notably, in predicting drug response, CAAs substantially outperform \ua0mutations and focal deletions/amplifications combined. Thus, CAAs predict cancer prognosis, shape tumour evolution, metastasis and drug response, and may advance precision oncology